Cortexin
14 indexed publications · 8 human studies · research from 1999 to 2026
Research goals studied
- Bone, muscle & performance
- Immune function
- Metabolic & glucose
- Mood, stress & sleep
- Neuro & cognition
Studies referencing Cortexin
Cortexin in the Comprehensive Therapy of Alcohol-Related Disorders
2026 · Human evidence
Clinical report from a 2025 treatment cohort; full protocol and controlled-comparison details require review.
Efficacy and Safety of Cortexin as Additional Therapy in Patients with Depressive Disorder
2026 · Human evidence
The indexed report describes Cortexin as adjunctive therapy; independent replication and full protocol appraisal are needed.
Therapeutic Equivalence of Intravenous and Intramuscular Cortexin in Acute Ischemic Stroke
2025 · Human evidence
Reported intravenous administration as non-inferior to intramuscular administration for functional recovery outcomes.
Neurotropic Effects of Cortexin on Models of Mental and Neurological Disorders
2025 · Preclinical
Reported neurobehavioral effects across animal models; findings are preclinical.
Cortexin Effects in a High-Glucose Model of Peripheral Neuropathy
2023 · Preclinical
Examined Cortexin under high-glucose injury conditions; this is mechanistic preclinical evidence.
Comparative Efficacy of Cellex and Cortexin in Patients with Chronic Cerebral Ischemia
2020 · Human evidence
Compared two peptide-containing preparations on neurological and cognitive outcomes.
Dose-Dependent Effects of Cortexin in Chronic Cerebral Ischemia
2018 · Human evidence
Reported dose-related changes in neurological, asthenic, sleep, anxiety and depressive symptoms in 189 patients.
Results of a Multicenter Study on the Efficacy of Cortexin in Children with Cognitive and Behavioral Disorders
2018 · Human evidence
The study included 635 children and reported improvements across selected clinical scales; blinding and control details require full-text review.
Molecular Mechanisms of Brain Peptide-Containing Drugs
2018 · Preclinical
Reviews proposed antioxidant, anti-inflammatory and neurotrophic mechanisms of brain peptide preparations.
Peptide Drug Cortexin Inhibits Brain Caspase-8
2017 · Preclinical
Reported stronger inhibition of caspase-8 than several other proteases in the studied model.
An Open Clinical Trial of Cortexin in Treatment of Brain Ischemia with Cognitive and Affective Disorders
2014 · Human evidence
Evaluated cognitive and affective outcomes in brain ischemia; open-label design limits causal inference.
Pinealon and Cortexin in Rats with Carotid Artery Occlusion
2011 · Preclinical
Compared Pinealon and Cortexin in a carotid-occlusion model.
Comparison of Behavioral Effects of Cortexin and Cerebrolysin Injected into Brain Ventricles
2007 · Preclinical
Both preparations produced psychoactivating effects in rats; Cortexin effects were stronger in the reported tests.
Cortexin in the Treatment of Circulatory Encephalopathy
1999 · Human evidence
Early clinical report; details require review of the Russian-language full text.
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