Epitalon (AEDG)
48 indexed publications · 1 human studies · research from 2000 to 2026
Research goals studied
- Cancer & oncology
- Cardiovascular
- Delivery & pharmacokinetics
- Eye & vision
- Gene & DNA regulation
- Gut & digestion
- Hormonal & reproductive
- Immune function
- Longevity & aging
- Metabolic & glucose
- Mood, stress & sleep
- Neuro & cognition
- Skin & tissue repair
Studies referencing Epitalon (AEDG)
Therapeutic Peptides in Gerontology: Mechanisms and Applications for Healthy Aging
2026 · Preclinical
Reviews nine peptides, including Epitalon and Semax, and stresses that long-term safety and systematic clinical validation remain limited.
Epitalon Increases Telomere Length in Human Cell Lines through Telomerase Upregulation or ALT Activity
2025 · Preclinical
Reported telomere-length increases in normal and cancer cell lines through different telomere-maintenance pathways; cancer-cell findings require particular caution.
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
2025 · Preclinical
Summarizes preclinical and limited clinical literature on Epitalon and identifies substantial evidence and safety gaps.
Epitalon-Activated Telomerase Enhances Bovine Oocyte Maturation and Post-Thaw Embryo Quality
2025 · Preclinical
Reported improved oocyte, cumulus-cell and post-thaw blastocyst quality in a bovine laboratory model.
Epitalon Peptide Mitigates High-Glucose-Induced Dysfunction in Retinal Pigment Epithelial Cells
2025 · Preclinical
In a high-glucose ARPE-19 model, Epitalon improved wound closure and reduced oxidative-stress and fibrotic markers; no human outcome was tested.
Epitalon Improves In Vitro Maturation and Developmental Competence of Bovine Oocytes
2022 · Preclinical
Investigated Epitalon during bovine oocyte maturation; the findings are preclinical and do not establish human fertility effects.
AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts
2022 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro
2021 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Peptide Regulation of Gene Expression: A Systematic Review
2021 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
AEDG Peptide Regulates the Expression of Circadian Genes Clock, Cry2, Csnk1e in Human Immune Cells
2021 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Peptide Regulation of Cell Differentiation
2020 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
2020 · Preclinical
Reported changes in neural-differentiation markers and gene expression in cell culture.
Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes
2019 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland
2017 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
The Peptide Ala-Glu-Asp-Gly and Interferon Gamma: Their Role in Immune Response during Aging
2013 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Geroprotective Effect of Ala-Glu-Asp-Gly Peptide in Male Rats Exposed to Different Illumination
2008 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Ala-Glu-Asp-Gly Peptide on Life Span and Development of Spontaneous Tumors in Female Rats Exposed to Different Illumination Regimes
2007 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Expression of Argyrophilic Proteins in the Nucleolar Organizer Regions of Human Thymocytes and Thymic Epitheliocytes under Conditions of Coculturing with Vilon and Epithalon Peptides
2004 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Epitalon on Free Radical Oxidation Processes in Campbell Rats
2004 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages
2003 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Epitalon on Biomarkers of Aging, Life Span and Spontaneous Tumor Incidence in Female Swiss-Derived SHR Mice
2003 · Preclinical
Did not increase mean lifespan, but reported changes in maximum lifespan and selected tumor outcomes in mice.
Effect of Synthetic Pineal Tetrapeptide (Ala-Glu-Asp-Gly) on Melatonin Secretion by the Pineal Gland of Young and Old Rats
2003 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Epitalon and Colon Carcinogenesis in Rats: Proliferative Activity and Apoptosis in Colon Tumors and Mucosa
2003 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Peptide Epitalon Activates Chromatin at Old Age
2003 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
2003 · Preclinical
Reported telomerase activation and telomere elongation in cultured human cells.
Effect of Retinalamin and Epithalon on Proliferation of Retinal and Pigment Epithelial Cells
2003 · Preclinical
Compared retinal peptide preparations and Epithalon in cultured retinal and pigment epithelial cells.
Effect of Epithalon on Age-Specific Changes in the Retina in Rats with Hereditary Pigmentary Dystrophy
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Epitalon on Interleukin-1 Beta Signal Transduction and the Reaction of Thymocyte Blast Transformation under Stress
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Inhibitory Effect of Peptide Epitalon on Colon Carcinogenesis Induced by 1,2-Dimethylhydrazine in Rats
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Inhibitory Effect of the Peptide Epitalon on the Development of Spontaneous Mammary Tumors in HER-2/NEU Transgenic Mice
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Epitalon Influences Pineal Secretion in Stress-Exposed Rats in the Daytime
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effects of Epithalon on Activities of Gastrointestinal Enzymes in Young and Old Rats
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Vilon and Epithalon on Glucose and Glycine Absorption in Various Regions of Small Intestine in Aged Rats
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Effect of Vilon and Epithalon on Activity of Enzymes in Epithelial and Subepithelial Layers in Small Intestine of Old Rats
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Pineal-Regulating Tetrapeptide Epitalon Improves Eye Retina Condition in Retinitis Pigmentosa
2002 · Human evidence
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart Using DNA-Microarray Technology
2002 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
2001 · Preclinical
Title-level bibliographic record. Consult the primary article before interpreting outcomes, methods, sample size, or safety.
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