Semax
21 indexed publications · 5 human studies · research from 1997 to 2026
Research goals studied
- Cardiovascular
- Delivery & pharmacokinetics
- Gene & DNA regulation
- Immune function
- Longevity & aging
- Mood, stress & sleep
- Neuro & cognition
- Skin & tissue repair
Studies referencing Semax
Therapeutic Peptides in Gerontology: Mechanisms and Applications for Healthy Aging
2026 · Preclinical
Reviews nine peptides, including Epitalon and Semax, and stresses that long-term safety and systematic clinical validation remain limited.
The Potential of the Peptide Drug Semax and Its Derivative for Therapeutic and Corrective Strategies in Alzheimer's Disease
2025 · Preclinical
Reported behavioral and molecular effects of Semax-related compounds in preclinical models.
The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain
2021 · Preclinical
Rat ischemia study examining Semax effects on pro-inflammatory transcript expression.
Semax as a Synthetic ACTH(4-10) Analogue in Ischemic Brain Injury
2021 · Preclinical
Summarizes neuroprotective pathways and preclinical ischemia findings.
Semax Alters the Brain Proteomic Profile after Ischemic Injury
2021 · Preclinical
Identified protein-expression changes after Semax in an ischemia model.
RNA-Sequencing Analysis of Semax Effects after Transient Middle Cerebral Artery Occlusion
2020 · Preclinical
Reported gene-expression changes in rat brain after transient ischemia and Semax treatment.
Effects of Semax and Selank on Resting-State Functional Connectivity
2020 · Human evidence
Examined acute changes in resting-state network connectivity after intranasal peptides in healthy participants.
Immunocorrective Effects of Semax
2019 · Preclinical
Reported immunomodulatory effects in an experimental model.
Semax Effects on Resting-State Brain Networks in Healthy Volunteers
2018 · Human evidence
Human neuroimaging study examining acute Semax-related network changes.
Semax in Rehabilitation after Ischemic Stroke and Its Relationship to BDNF
2018 · Human evidence
Evaluated neurological recovery and BDNF-related measures during post-stroke rehabilitation.
Peptides Semax and Selank Affect the Behavior of Rats with 6-OHDA-Induced Dopaminergic System Damage
2017 · Preclinical
Compared behavioral effects of Semax and Selank after 6-OHDA dopaminergic injury.
Semax, an Analog of ACTH(4-7), Regulates Expression of Immune Response Genes During Ischemic Brain Injury in Rats
2017 · Preclinical
Examined Semax-associated gene-expression changes after experimental brain ischemia.
The Peptide Semax Affects the Expression of Genes Related to the Immune and Vascular Systems in Rat Brain Focal Ischemia
2014 · Preclinical
Reported early gene-expression changes after focal cerebral ischemia.
Semax and Pro-Gly-Pro Stimulate Cell Proliferation after Ischemic Injury
2011 · Preclinical
Reported increased proliferative-cell markers after ischemic injury.
Nootropic and Analgesic Effects of Semax Following Different Routes of Administration
2010 · Preclinical
Compared intraperitoneal and intranasal Semax in rats using learning and pain-sensitivity tests.
Specific Binding of Semax and Its Effect on BDNF Expression in Rat Brain
2006 · Preclinical
Investigated Semax binding and associated BDNF-expression changes.
Semax Regulates the Expression and Activation of the Hippocampal BDNF/trkB System
2006 · Preclinical
Assessed hippocampal BDNF/trkB responses after Semax administration.
Neuroprotective Effects of Semax in MPTP-Induced Disturbances of the Dopaminergic System
2002 · Preclinical
Evaluated behavioral and neuroprotective effects of Semax in an MPTP rat model.
Semax and Selank Inhibit Enkephalin-Degrading Enzymes in Human Serum
2001 · Preclinical
Tested effects of Semax and Selank on enzymes involved in enkephalin degradation.
Semax in Acute Ischemic Stroke: Clinical and Mechanistic Observations
1999 · Human evidence
Early clinical report; treatment allocation and masking require full-text appraisal.
Semax in the Treatment of Patients at Different Stages of Ischemic Stroke
1997 · Human evidence
Early clinical report of Semax use at different stages of ischemic stroke; full protocol appraisal is required.
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